"Induction of leukaemic cell death by drug combination", is another entry to the Natural Science Seminar Series. This Seminar will be presented by Dr Milan Vu.
Relapsed acute myeloid leukaemia cells are difficult to eradicate, due in part to their more refractory nature and mutations that can lead to deregulation of certain proteins, which regulates cell death through apoptosis, autophagy and other cellular processes.
Using chemical agents could modulate these signalling pathways. Established chemotherapy drug doxorubicin and phytochemical betulinic acid may complement each other in sensitising and eradicating aggressive AML cells. This study investigated their possible synergistic and/or additive effects, which may show a more selective cell killing effect.